Palmistry 

What affects growth hormone. Increasing growth hormone in a natural way - rejuvenation and healing of a person. Ways to increase somatotropin at home

Somatotropin, or growth hormone, from the group of peptides is produced by the body in the anterior pituitary gland, but the secretion of the substance can be increased naturally. The presence of this component in the body enhances lipolysis, which burns subcutaneous fat, and builds muscle mass. For this reason, it is of particular interest to athletes who seek to improve their athletic performance. To achieve this, it is worth studying in more detail the synthesis process and other features of this substance.

What is somatotropin

This is the name of a peptide hormone synthesized by the anterior pituitary gland. The main property is the stimulation of cell growth and repair, which contributes to the growth of muscle tissue, bone density. From the Latin "soma" meaning body. The recombinant hormone got its name due to its ability to accelerate growth in length. Somatotropin belongs to the family of polypeptide hormones along with prolactin and placental lactogen.

Where is formed

This substance is produced in the pituitary gland - a small endocrine gland, about 1 cm. It is located in a special recess at the base of the brain, which is also called the "Turkish saddle". A cellular receptor is a protein with a single intramembrane domain. The pituitary gland is controlled by the hypothalamus. It stimulates or inhibits the process of hormonal synthesis. The production of somatotropin has a wave-like character - several bursts of secretion are observed during the day. The largest number is noted 60 minutes after falling asleep at night.

What is it needed for

Already by the name it can be understood that somatropin is necessary for the growth of bones and the body as a whole. For this reason, it is more actively produced in children and adolescents. At the age of 15-20 years, the synthesis of growth hormone gradually declines. Then the period of stabilization begins, and after 30 years - the stage of decline, which lasts until death. For the age of 60 years, the production of only 40% of the somatotropin norm is typical. Adults need this substance to restore torn ligaments, strengthen joints, and heal broken bones.

Action

Among all pituitary hormones, somatotropin has the highest concentration. It is characterized by a large list of actions that the substance produces on the body. The main properties of growth hormone are:

  1. Acceleration of linear growth in adolescents. The action is to lengthen the tubular bones of the limbs. This is possible only in the prepubertal period. Further growth is not carried out due to endogenous hypersecretion or exogenous influx of GH.
  2. Increased lean muscle mass. It consists in inhibition of protein breakdown and activation of its synthesis. Somatropin inhibits the activity of enzymes that destroy amino acids. It mobilizes them for the processes of gluconeogenesis. This is how the hormone for muscle growth works. It is involved in protein synthesis, enhancing this process, regardless of the transport of amino acids. Works in conjunction with insulin and epidermal growth factor.
  3. Formation of somatomedin in the liver. This is the name of insulin-like growth factor, or IGF-1. It is produced in the liver only under the action of somatotropin. These substances work in conjunction. The growth-stimulating effect of GH is mediated by insulin-like factors.
  4. Reducing the amount of subcutaneous fat. The substance contributes to the mobilization of fat from its own reserves, due to which the concentration of free fatty acids in the plasma increases, which are oxidized in the liver. As a result of the increased breakdown of fats, energy is generated that goes to enhance protein metabolism.
  5. Anti-catabolic, anabolic action. The first effect is the inhibition of the breakdown of muscle tissue. The second action is to stimulate the activity of osteoblasts and activate the formation of the protein matrix of the bone. This leads to muscle growth.
  6. Regulation of carbohydrate metabolism. Here the hormone is an insulin antagonist, i. acts opposite to it, inhibiting the use of glucose in tissues.
  7. Immunostimulatory effect. It consists in activating the cells of the immune system.
  8. Modulating effect on the functions of the central nervous system and the brain. According to some studies, this hormone can cross the blood-brain barrier. Its receptors are found in some parts of the brain and spinal cord.

Somatotropin secretion

Most somatotropin is produced by the pituitary gland. The full 50% of the cells are called somatotropes. They produce the hormone. It got its name because the peak of secretion falls on the phase of rapid development in adolescence. The saying that children grow up in their sleep is entirely justified. The reason is that the maximum secretion of the hormone is observed in the first hours of deep sleep.

The basic rate in the blood and peak fluctuations during the day

The normal content of somatropin in the blood is about 1-5 ng / ml. During peak concentrations, the amount rises to 10-20 ng / ml, and sometimes even up to 45 ng / ml. There may be several such jumps during the day. The intervals between them are about 3-5 hours. The most predictable highest peak occurs for a period of 1-2 hours after falling asleep.

Age changes

The highest concentration of somatropin is observed at the stage of 4-6 months of intrauterine development. This is about 100 times more than an adult. Further, the concentration of the substance begins to decrease with age. This happens between the ages of 15 and 20. Then comes the stage when the amount of somatropin remains stable - up to 30 years. Subsequently, the concentration again decreases until old age. At this stage, the frequency and amplitude of secretion peaks decrease. They are maximum in adolescents during intensive development during puberty.

What time is produced

About 85% of somatropin is produced between 12 and 4 in the morning. The remaining 15% is synthesized during daytime sleep. For this reason, for normal development, children and adolescents are advised to go to bed no later than 21-22 hours. Also, don't eat before bed. Food stimulates the release of insulin, which blocks the production of somatropin.

In order for the hormone to benefit the body in the form of weight loss, you need to sleep at least 8 hours a day. It is better to lie down before 23:00, because the largest amount of somatropin is produced from 23:00 to 2:00 in the morning. Immediately after waking up, you should not have breakfast, because the body still continues to burn fat due to the synthesized polypeptide. It is better to postpone the morning meal for 30-60 minutes.

Secretion regulation

The main regulators of somatotropin production are the peptide hormones of the hypothalamus - somatoliberin and somatostatin. Neurosecretory cells synthesize them into the portal veins of the pituitary gland, which directly affects somatotropes. The hormone is produced due to somatoliberin. Somatostatin, on the contrary, suppresses the secretion process. Somatropin synthesis is influenced by several different factors. Some of them increase the concentration, while others, on the contrary, decrease it.

What factors contribute to the synthesis

It is possible to increase the production of somatropin without the use of medications. There are a number of factors that contribute to the natural synthesis of this substance. These include the following:

  • thyroid loads;
  • estrogens;
  • ghrelin;
  • full sleep;
  • hypoglycemia;
  • somatoliberin;
  • amino acids - ornithine, glutamine, arginine, lysine.

    • Factors causing deficiency

    Secretion is also affected by some xenobiotics, chemicals that are not part of the biotic cycle. Other factors that lead to hormone deficiency are:

    • hyperglycemia;
    • somatostatin;
    • high blood levels of free fatty acids;
    • increased concentration of insulin-like growth factor and somatotropin (most of it is associated with a transport protein);
    • glucocorticoids (hormones of the adrenal cortex).

    What causes an excess of somatotropic hormone

    If in adults the level of somatropin is equal to the concentration that is typical for a growing organism, then this is considered an excess of this hormone. This condition can lead to serious health problems. These include:

    1. Acromegaly and gigantism. The first concept is an increase in the size of the tongue, a strong thickening of the bones and coarsening of facial features. Gigantism is characteristic of children and adolescents. The disease is manifested by a very large growth, a proportional increase in bones, organs, soft tissues. In women, this figure can reach 190 cm, and in men - 200 cm. Against this background, small head sizes, an increase in the size of internal organs and lengthening of the limbs are noted.
    2. tunnel syndrome. Pathology is a numbness of the fingers and hands, accompanied by tingling pain in the joints. Symptoms appear due to compression of the nerve trunk.
    3. tissue insulin resistance. This is the name of the violation of the biological response of body tissues to the action of insulin. As a result, sugar cannot pass from the blood into the cells. Because of this, the concentration of insulin is constantly at a high level, which leads to obesity. The result is that you can’t lose weight even on a strict diet. All this is accompanied by hypertension and edema. Insulin resistance increases the risk of cancer, type 1 diabetes, heart attacks, atherosclerosis, and even sudden death due to blockage of blood vessels.

    The consequences of a lack of growth hormone

    For the human body, not only an excess of somatropin is catastrophic, but also a deficiency. A deficiency of this substance leads to a weakening of emotional reactions, a decrease in vitality, increased irritability and even depression. Other consequences of somatropin deficiency are:

    1. Pituitary dwarfism. This is an endocrine disease, which is a violation of the synthesis of somatropin. This condition causes a delay in the development of internal organs, the skeleton. Mutations in the GH receptor gene are manifested by abnormally short stature: in men it is about 130 cm, and in women it is less than 120 cm.
    2. Delayed physical and mental development. This pathology is observed in children and adolescents. In 8.5% of them, short stature is observed due to a lack of somatropin.
    3. Delayed puberty. With this pathology, there is an underdevelopment of secondary sexual characteristics in comparison with most other adolescents. Delayed puberty is caused by a slowdown in overall physical development.
    4. Obesity and atherosclerosis. In violation of the synthesis of somatropin, a failure of all types of metabolism is observed. This is what causes obesity. Against this background, a large amount of free fatty acids is observed in the vessels, which can cause their blockage, which will lead to atherosclerosis.

    How is somatotropin used?

    This substance can also be synthesized artificially. In the very first production experiment, an extract of the human pituitary gland was used. Somatropin until 1985 was extracted from human corpses, so it was called cadaveric. Today, scientists have learned how to synthesize it artificially. In this case, the possibility of infection with Creutzfeldt-Jakob disease is excluded, which was possible when using a cadaveric preparation of GR. This disease is a fatal pathology of the brain.

    The FDA-approved drug based on somatropin is called Somatrem (Protropin). Therapeutic use of this remedy:

    • treatment of nervous disorders;
    • accelerating the growth of children;
    • fat loss and muscle building;

    Another area of ​​​​use of Somatrem is the prevention of senile diseases. In older people, GH leads to an increase in bone density, increased mineralization, a decrease in adipose tissue and an increase in muscle mass. In addition, they have a rejuvenation effect: the skin becomes more elastic, wrinkles are smoothed out. The downside is the manifestation of several adverse reactions, such as arterial hypertension and hyperglycemia.

    In the treatment of nervous disorders

    Somatropin improves memory and cognitive functions. This is especially necessary for patients with pituitary dwarfism. As a result, a patient with a low content of somatotropin in the blood improves well-being and mood. An increased level of this substance is also not recommended, because it can cause the opposite effect and cause depression.

    With pituitary dwarfism

    Treatment of developmental disorders in children is possible through stimulation by daily administration of pituitary extract. It affects not only one gland, but also the body as a whole. It is worth using such injections as early as possible and until the end of puberty. To date, a course of growth hormone is the only effective way to treat pituitary dwarfism.

    Peptides in bodybuilding

    The effect of burning fat and increasing muscle mass is especially often used by professional bodybuilders during active training. Athletes take peptides for muscle growth in combination with testosterone and other drugs with a similar effect. The use of Somatrem was banned in 1989 by the International Olympic Committee, but this did not rule out the illegal use of this drug. In combination with GH, bodybuilders use the following drugs:

    1. Steroids. Their powerful anabolic action enhances the hypertrophy of muscle cells, which accelerates their development.
    2. Insulin. It is necessary to relieve the burden on the pancreas, which, due to an increase in the level of GH, begins to work too actively and depletes its reserves.
    3. Thyroid hormones of the thyroid gland. In a small dose, they exhibit an anabolic effect. Taking thyroid hormones speeds up metabolism and accelerates tissue growth.

    How to Increase Growth Hormone Production

    There are different growth hormone stimulants. One of them is taking certain medications. Although natural methods also help to increase the production of somatropin. For example, in people who exercise regularly, the effects of IGF-1 and GH are enhanced. This was not observed in untrained subjects. Somatropin synthesis also occurs throughout sleep, so it is very important that a person sleeps normally. The intake of multivitamin complexes helps to increase the amount of GH produced, including:

    • minerals;
    • vitamins;
    • amino acids;
    • natural adaptogens;
    • substances of plant origin - chrysin, forskolin, griffonia.

    Somatotropin tablets

    Even though the substance is officially banned in sports, the temptation to use it is very high. For this reason, many athletes still resort to this method to remove excess adipose tissue, tighten their figure and gain more relief. The advantage of its use is the strengthening of bones. If the athlete is injured, which happens very rarely, then taking somatropin accelerates healing. The drug has a number of side effects, such as:

    • increased fatigue and loss of strength;
    • development of scoliosis;
    • pancreatitis - inflammation of the pancreas;
    • loss of clarity of vision;
    • accelerated muscle development and compression of peripheral nerves;
    • bouts of nausea and vomiting;
    • joint pain.

    Even with the positive effects of the drug, some people should not use it. Contraindications include the following pathologies:

    • allergy to the components of the drug;
    • malignant tumors;
    • a threat to life in the form of a postoperative period and acute respiratory failure;
    • pregnancy and lactation.

    Caution must be observed in hypothyroidism, hypertension and diabetes mellitus. It is important at the time of taking growth hormone to give up alcohol. Disputes about the dangers of using this substance are still going on. According to some experts, the risk of use is limited to an increase in the amount of glucose in the blood and the appearance of swelling. Although there have been cases of an increase in the size of the liver and even legs, this only applies to cases of exceeding the dosage.

    What products contain

    No less important for increasing the production of somatotropin is proper nutrition. It must be balanced. It is recommended to give preference to lean foods, because fatty foods cause a decrease in GH. The list of foods that include protein and other substances necessary for recuperation and raising the level of somatotropin includes:

    • cottage cheese;
    • chicken eggs;
    • buckwheat and oatmeal;
    • veal;
    • legumes;
    • milk;
    • poultry meat;
    • nuts;
    • fish;
    • lean beef;

    Physical activity

    Almost any motor activity has a positive effect on the secretion of somatropin. It can be regular walking or weightlifting. Although some types of loads are more efficient. Sports divide them into two groups - power (anaerobic) and aerobic (cardio). The first group includes heavy lifting for a short time. Aerobic exercise includes walking, running, skiing, cycling, etc. To increase the production of GR, it is necessary to reasonably combine these two types of exercise. The most useful are:

    • weight training with a number of repetitions from 10 to 15;
    • walking at an approximate speed of 4-6 km / h.

    A complete night's sleep

    For the synthesis of somatropin, a full sleep for 8 hours is necessary. Natural production begins 1.5-2 hours after falling asleep. This is the deep sleep phase. When a person does not have the opportunity to spend the allotted time sleeping at night, then it is imperative to rest at least 1-2 hours during the day. Even regular exercise and a healthy diet with lack of sleep will not give the desired result.

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    Every person wants to look attractive. In recent years, the ideal of beauty has become tall and athletic fit figure. Many want to achieve this without much effort. Therefore, more and more people have become interested: is it possible to buy growth hormone in a pharmacy.

    Why exactly this drug? Manufacturers of growth hormones promise many positive effects from their intake. Athletes used to acquire such drugs on the black market and use them to quickly build muscle mass. And in recent years it has become possible to buy growth hormones in a pharmacy. So there is more confidence that they will be of high quality. But before you start taking the hormone, you need to consult a doctor, as this is a serious substance that has many contraindications and side effects.

    What is growth hormone

    In the pharmacy, you can buy several different drugs containing somatropin. This is the name of growth hormone produced by the anterior lobe of the human pituitary gland. It is produced throughout life, especially actively up to 20-25 years, then its formation slows down. This hormone, like others, is necessary for the normal functioning of the body.

    In addition to stimulating growth and development in childhood and adolescence, it affects the formation of muscles and bones, as well as fat metabolism in the body and even heart function. Its production is accelerated under the influence of some other hormones and amino acids, during sleep and exercise. But sometimes a person experiences a lack of somatropin. This may be due to high levels of sugar or fatty acids in the blood, an increased amount of insulin, or other reasons. In this case, the doctor recommends buying growth hormone in a pharmacy and taking it additionally.

    artificial growth hormone

    This substance was discovered in the middle of the 20th century. Initially, growth hormone was used for medical purposes and was used to accelerate the growth of children with slow development. But then some of its other properties were discovered, for example, the ability to increase muscle mass and reduce body fat. Therefore, it began to be actively used in sports. But since 1989, somatropin has been banned by the Olympic Committee. Despite this, now in our country you can freely buy muscle growth hormones in a pharmacy. Athletes use them, especially in bodybuilding, because these drugs not only help build muscle mass, but also burn subcutaneous fat.

    How are growth hormones obtained?

    At first, such preparations were made on the basis of extracts from the pituitary gland of corpses. These hormones had many side effects. And this method was banned all over the world.

    It was not until the 1980s that an industrial method for the production of growth hormones was discovered. Now they are obtained in two ways:

    • Recombinant or genetically modified growth hormone the easiest way to buy in a pharmacy. It is obtained from the bacterium Escherichia coli. If you influence her genes, then under the influence of certain conditions, she will produce a growth hormone that is very close to natural. It is best tolerated, and the body almost does not produce antibodies to it.
    • synthetic growth hormone produced chemically. Its first 24 amino acids are synthesized artificially, and the rest are taken from human pituitary RNA.

    What is growth hormone used for?

    This drug has many positive properties. Most often it is used for medical purposes. It is used to treat sick children with insufficiency of the pituitary gland, which slows down development. The use of this hormone before puberty helps not only increase growth, but also build muscle mass, as well as improve metabolism. It is used for certain hormonal diseases, dystrophy or pituitary dwarfism.


    But most often growth hormones are used by athletes. These drugs help them not only increase muscle mass in a short time, but also reduce the risk of injury by strengthening the joints. And recent studies have proven the positive effect of the use of growth hormones to rejuvenate the body. Due to the huge demand for such drugs, there are a large number of fakes on the market. Therefore, so many people are interested in whether it is possible to buy growth hormone in a pharmacy. After all, there drugs are certified.

    Positive properties of the drug

    What gives the reception of this substance:

    • increased endurance, muscle tone and performance;
    • strengthening the skeleton;
    • hair restoration: they will become thicker, stop falling out, and gray hair will disappear;
    • improvement of mood, protection against depression and stress;
    • disappearance of wrinkles, facial skin rejuvenation;
    • improvement of memory, thought processes and vision;
    • normalization of pressure and cholesterol levels;
    • reduction of body fat;
    • acceleration of tissue regeneration, wound healing;
    • strengthening immunity;
    • normalization of metabolism.

    Why did this drug become popular?

    Everyone wants to be healthy and look younger without much effort. Most are not ready to change their lifestyle and go in for sports, they need a "magic" pill that can make them attractive. And after research in the 90s, when growth hormone preparations were given to the elderly, an article was published that described the positive results of such actions. The problem of aging in the modern world is very relevant, and the pharmaceutical industry has gone to meet the desire of people to look younger.

    Now growth hormones in a pharmacy can be purchased freely. And everyone who is not afraid of their high price is trying to become young and beautiful with their help. But doctors warn against such a frivolous attitude to taking medications. Contrary to the claims of advertising, growth hormones have many side effects. Therefore, it is recommended to use them only for medical reasons.

    Side effects of growth hormones

    They appear mainly when using a low-quality drug, non-compliance with the conditions of its storage or overdose. Usually, the side effects disappear after the growth hormone is stopped.

    The main manifestations include:

    • swelling and tunnel syndrome in the extremities;
    • the risk of developing cancerous tumors;
    • the possibility of developing diabetes;
    • increased blood pressure;
    • abnormal bone growth, hardening of the arteries;
    • headaches and muscle weakness;
    • increased cholesterol levels;
    • pain in muscles and joints;
    • changes in the functioning of the thyroid gland, up to the development of thyrotoxicosis;
    • increase in blood sugar levels.

    Why you need to buy growth hormones in a pharmacy

    For people seeking to improve their body, it is enough to advertise the positive qualities of the drug, and they are ready to buy it even from a stranger. But customer reviews show that more than 70% of growth hormones sold in our country are counterfeit. At best, they do not bring any effect, since they contain very little somatropin.

    In addition, real growth hormone requires special storage conditions. It does not tolerate sunlight and temperatures above 20 degrees. Therefore, it is best to buy it in a pharmacy. It is there that you can buy certified drugs that will work as you need. They are licensed and stored correctly. Poor-quality drugs often lead to side effects and the formation of antibodies, due to which growth hormones will no longer act on a person.

    What form are the drugs in?

    • Powder for solution for injection. It is believed that growth hormone is more effective in this form, since its active ingredient is rather unstable and requires a special temperature for storage, as well as adherence to the exact dosage.
    • Recently you can buy Manufacturers describe the same positive properties of taking these drugs, but doctors are skeptical about this form of somatropin. They believe that the hormone will be digested in the stomach before it starts working.

    What are growth hormones

    All over the world, the industry produces many such drugs. But not all of them are of high quality. In our country, growth hormone preparations are not very common in pharmacies. We offer the following medicines:

    • "Ansomon" is considered the best drug for burning fat, so it has a lot of fakes. It is produced in China, but is not inferior in quality to European drugs.
    • "Jintropin" is the most famous all over the world, especially among athletes. The drug has protection against fakes, and in a pharmacy under this name you can buy real growth hormone.
    • The third somatropin certified in Russia is Dinatrop, produced in Iran.

    There are several other European drugs that can sometimes be found in Russian pharmacies. The highest quality of them are Genotropin, Norditropin and Saizen. A few years ago, a Russian pharmaceutical company began to produce growth hormone in powder for injection called Rastan.

    Which is better: injections or pills?

    It is believed that a living hormone can exist only in powder. It is diluted with a special solvent and injected. Only in this way the substance enters the blood immediately and begins to act. But in recent years, you can buy growth hormone in a pharmacy in tablets. The name of such drugs is known mainly to athletes or people interested in quick ways of rejuvenation. Doctors are doubtful about this intake of somatropin, believing that the hormone does not have time to get into the blood, being digested in the stomach. But manufacturers, advertising their drugs, describe many of their positive properties, which do not differ from the effect of injections.

    The most famous in our pharmacies are such drugs:

    • "Winstrol", "Stromba", "Wintrop" are drugs with one active ingredient, but produced by different companies. It is believed that you can achieve the same effect as from injections by taking at least 12 tablets per day;
    • Symbiotropin is a dietary supplement in the form of effervescent, instant tablets. This form of the drug allows it to quickly penetrate into the bloodstream and act in the same way as injections.

    How can you stimulate your own hormone

    For many, it is unrealistic to purchase such drugs because of their too high price. But growth hormone is produced in the human pituitary gland throughout life, so in the absence of hormonal diseases, its production can be stimulated. What is needed for this:

    • sleep enough;
    • exercise regularly;
    • avoid foods with a high glycemic index;
    • exclude food before bedtime;
    • remove fat deposits on the abdomen;
    • you can also buy growth hormone stimulants in a pharmacy: the amino acids L-arginine, glycine and glutamine.

    A growth hormone(aka growth hormone, STH, HGH, somatotropin or somatropin) is a peptide hormone of the anterior pituitary gland, so named primarily because it can increase body length in young people in the age group up to 20-25 years. In addition, growth hormone causes muscle growth and inhibits their destruction, reduces body fat, maintains a high rate of metabolic processes, accelerates wound healing, has a rejuvenating effect, stimulates collagen production, thereby smoothing the skin and increasing its elasticity, activates the sex glands, increasing the level of sexuality, as well as strengthens the bones and joints.

    The aging of the body is directly related to the level of growth hormone. Its secretion is maximum at the age of 20 years, and then decreases at a rate of 15-17% per decade, it is minimal in the elderly, when both the base level and the frequency and amplitude of secretion peaks decrease. Due to the decrease in the production of somatotropin, we stop growing and begin to gain weight.

    It is not surprising that interest in this hormone is so great, especially among those who are professionally engaged in bodybuilding. Growth hormone injections help to get the desired shape, but the price of such drugs is quite high and they are not safe. Few people know that it is possible to increase the content of the hormone in a natural way and there is no need to resort to “chemistry”. At the same time, you are not threatened with becoming a pile of muscles, but a slender and toned body is provided.

    The natural secretion of growth hormone depends on a number of factors, including age, sex, nutrition, stress, levels of other hormones (such as sex steroids, thyroid hormones), weight, level of physical fitness and movement.

    How to increase the production of growth hormone naturally?


    What inhibits the secretion of growth hormone:

    • hyperglycemia- elevated blood sugar levels.Elevated sugar levels are observed in diabetes, with eating disorders, for example, with bulimia nervosa, when a person does not control the amount of food eaten and, accordingly, receives a huge calorie content at one meal. The abuse of carbohydrate foods that increase insulin synthesis seriously interferes with the work of growth hormone. HYou should also eat carbohydrates before bed. The peculiarity of growth hormone is that it likes to use fat as fuel and reduces its amount in the body, especially during sleep. When carbohydrates are consumed, insulin is released, a hormone whose function is to convert excess glucose into fat. Growth hormone and insulin are hormone antagonists, i.e. insulin suppresses the production of growth hormone. At night, you rest, so the carbohydrates eaten before bed will be deposited in fat, and the growth hormone will practically not work, and therefore will not “burn” it.
    • High blood lipids, overweight, sedentary lifestyle, unhealthy diet.
    • Glucocorticoids - These are steroid hormones produced by the adrenal cortex, the level of which rises sharply during chronic stress, trauma, blood loss, and shock conditions. They reduce the secretion of insulin-like growth factors by the liver in response to growth hormone and reduce the sensitivity of peripheral tissues to growth hormone, thereby inhibiting anabolic processes and linear growth.
    • Estradiol and other estrogens.
    • Alcohol. In addition to depleting vitamins and minerals, lowering testosterone, increasing estrogen, and dehydrating, alcohol inhibits muscle growth by suppressing the secretion of insulin-like growth factor GF-I and growth hormone. Their level decreases over the next 2 days by an average of 70%. In addition, alcohol disrupts sleep cycles, and as we already wrote, 85% of growth hormone is produced at this particular time.

    The maximum secretion of growth hormone is reached before the age of twenty years, then it decreases at an average rate of 15-17% at 10 years. Many 40-year-olds suffer from a lack of growth hormone - and without it it is difficult to talk about good muscle growth.

    The action of growth hormone (somatropin):

    1. Anabolic action (promotes the growth of muscle mass)
    2. Anti-catabolic effect (helps reduce the destruction of muscle mass)
    3. Reduces body fat
    4. Improves energy use
    5. Accelerates wound healing
    6. Has a rejuvenating effect
    7. Stimulates the re-growth of internal organs that have atrophied with age
    8. Strengthens bones, causes bone growth in people up to 26 years old (before the growth zones are closed)
    9. Raises Blood Glucose Levels
    10. Strengthens human immunity

    Below is a list of rules that will allow you to increase the level of growth hormone (somatropin) in a natural way:

    1. Eat complex carbohydrates with a low glycemic index before training. An example of such complex carbohydrates: Oats, pasta, wholemeal bran bread, brown rice, peas, colored beans, fresh fruit juice without sugar, dairy products.

    2. Good deep sleep. Sleep for at least 7-8 hours. Try to sleep well for 7-8 hours. Go to bed no later than 11.

    3. Go to bed with an empty stomach. The main amount of somatropin is released within 1 hour after falling asleep. And the level of sugar in the blood produces a release of insulin, which just lowers the level of the hormone (it is its antagonist).

    4. In addition, take the amino acids Arginine and Ornithine. You can find them at any sports nutrition store. The highest content of arginine can be found in pumpkin seeds, meat and milk.

    5. Eat 6-7 meals a day, portions should be small (every two to three hours). This technique also helps to lose weight, BUT do not overeat!

    6. Follow a balanced diet containing fats, proteins and carbohydrates in the right proportions.

    45-65% of calories should come from carbohydrates (preferably complex).

    20-35% from fat.

    10-35% from proteins.

    The ideal option is 30% proteins, 20% fats, 50% carbohydrates.

    7. Go to the bathhouse at least once a week.

    8. During training, perform basic exercises that require significant energy costs. These exercises include: barbell squats, deadlifts, barbell or dumbbell bench presses, pull-ups, parallel bars. It will also help men raise their most important hormone - testosterone, gain strength and a good body!

    9. If possible, allow yourself to take a nap during the day, But no more than two hours! The best option is 1 hour of good sleep.

    10. Try not to do the same exercises during training, diversify your workouts.

    The name of the hormone is somatropin. Only in adolescence and childhood is it useful for growth. The hormone is very important for people. Throughout human life, it affects metabolism, blood sugar levels, muscle development and fat burning. And also it can be synthesized artificially.

    Where and how is it produced?

    Growth hormone is produced by the anterior pituitary gland. The organ located between the cerebral hemispheres is called the pituitary gland. There, the most important hormones for people are synthesized that affect the nerve endings, and to a lesser extent - on other cells of the human body.

    Genetic factors influence the production of the hormone. To date, a complete genetic map of a person has been compiled. Growth hormone synthesis is controlled by five genes on the seventeenth chromosome. Initially, there are two isoforms of this enzyme.

    During growth and development, a person produces additionally several produced forms of this substance. To date, more than five isoforms have been identified that have been found in human blood. Each isoform has a specific effect on the nerve endings of various tissues and organs.

    The production of the hormone is produced from time to time with a period of three to five hours during the day. Usually an hour or two after falling asleep at night, there is the brightest surge in its production for the whole day. During a night's sleep, several more stages occur sequentially, only two to five times the hormone synthesized in the pituitary gland enters the bloodstream.

    It is proven that such a natural production of it falls with age. It reaches a maximum in the second half of the intrauterine development of the child, and then gradually decreases. The maximum frequency of production is reached in early childhood.

    In adolescence, during puberty, there is a maximum intensity of its production at a time, however, the frequency is much lower than in childhood. The minimum amount of it is produced in old age. At this time, both the frequency of production periods and the maximum amount of hormone produced at one time is minimal.

    Distribution of growth hormone in the human body

    To move within the body, he, like other hormones, uses the circulatory system. To achieve its goal, the hormone binds to its transport protein, which the body has developed.

    Subsequently, it moves to the receptors of various organs, affecting their work, depending on the isoform and the action of other hormones in parallel with somatropin. When it hits a nerve ending, somatropin causes an effect on the target protein. This protein is called Janus kinase. The target protein causes activation of glucose transport to target cells, their development and growth.

    The first type of impact

    Growth hormone owes its name to the fact that it acts on bone tissue receptors located in unclosed bone growth zones. This causes a strong growth of children, adolescents during puberty, caused by the growth hormone produced in the teenage body at this time in sufficient quantities. Most often this occurs due to an increase in the length of the tubular bones of the legs, bones of the lower leg, and hands. Other bones (such as the spine) also grow, but this is less pronounced.

    In addition to the growth of open areas of bones at a young age, it causes the strengthening of bones, ligaments, teeth throughout life. With a lack of synthesis of this substance in the human body, many diseases that elderly people suffer from can be associated - mainly diseases of the musculoskeletal system.

    The second type of impact

    This is an increase in muscle growth and fat burning. This type of exposure is widely used in sports and bodybuilding. Three types of methods are used:

    • increase the natural synthesis of the hormone in the body;
    • improvement in the absorption of somatropin associated with other hormones;
    • acceptance of synthetic substitutes.

    Today, somastatin preparations are prohibited doping. The International Olympic Committee recognized this in 1989.

    The third type of impact

    An increase in the amount of glucose in the blood due to the effect on liver cells. This mechanism is quite complex, and it allows you to track the relationship with other human hormones.

    Growth hormone is involved in many other types of activity - it acts on the brain, participates in the activation of appetite, affects sexual activity, and both the effect of sex hormones on the synthesis of somatotropin and its effect on the synthesis of sex hormones are observed. He even takes part in the learning process - experiments on mice showed that those individuals who were additionally injected with it learn better and develop conditioned reflexes.

    There are conflicting studies about the effect on the aging of the body. Most of the experiments confirm that the elderly, who were additionally injected with growth hormone, felt much better. They improved metabolism, general condition, showed activation of mental and physical activity. At the same time, animal experiments suggest that those individuals who received this drug artificially showed a shorter life expectancy than those who did not receive it.

    How is growth hormone related to other hormones?

    Two main substances influence the production of growth hormone. They are called somastatin and somalibertin. The hormone somastatin inhibits the synthesis of somatotropin, and somalibertin causes increased synthesis. These two hormones are produced in the same place, in the pituitary gland. The interaction and joint effect on the body of somatotropin is observed with such drugs:

    • IGF-1;
    • Thyroid hormones;
    • estrogen;
    • Adrenal hormones;

    This substance is the main mediator in the absorption of sugar by the body. When a growth hormone is exposed to a person, an increase in blood sugar is observed. Insulin causes it to decrease. At first glance, the two hormones are antagonists. However, this is not quite true.

    When exposed to the enzyme, sugar in the blood is more efficiently absorbed during the work of the cells of tissues and organs awakened by it. This allows you to synthesize certain types of protein. Insulin helps this glucose to be absorbed in order to work more efficiently. Therefore, these substances are allies, and the work of the hormone for growth is impossible without insulin.

    This is attributed to the fact that children who have type 1 diabetes grow much more slowly, and diabetic bodybuilders have difficulty building muscle if they have a lack of insulin. However, with too much somatropin in the blood, the activity of the pancreas can be "broken" and type 1 diabetes mellitus will occur. Somatropin affects the work of the pancreas that produces.

    IGF-1

    Factors affecting synthesis within the body

    Factors that increase the synthesis of somatropin:

    • influence of other hormones;
    • hypoglycemia;
    • good dream
    • physical activity;
    • stay in the cold;
    • Fresh air;
    • consumption of lysine, glutamine, some other amino acids.

    Reduce synthesis:

    • influence of other hormones;
    • high concentration of somatropin and IFP-1;
    • alcohol, drugs, tobacco, some other psychotropic substances;
    • hyperglycemia;
    • a large amount of fatty acids in the blood plasma.

    The use of growth hormone in medicine

    In medicine, it is used for diseases of the nervous system, the treatment of growth and developmental delays in childhood, the treatment of diseases of the elderly.

    Diseases of the nervous system associated with are effectively treated using synthetic substitutes for somatropin.

    It should be taken into account that the use of the drug in this case will in most cases cause a return to its original state, and a long course of its use can cause type 1 diabetes mellitus.

    Diseases associated with pituitary dwarfism - some types of dementia, depressive disorders, behavioral disorders. In psychiatry, this drug is used occasionally, during psychotherapy and the recovery period.

    In childhood, many children experience delays in growth and development. This is especially true for those whose mother during pregnancy took large doses of alcohol. The fetus can also be exposed to certain doses of alcohol, which cross the placental barrier and reduce growth hormone production. As a result, they initially have low levels of somatropin, and children need to take additional synthetic substitutes in order to catch up with their peers in their development.

    In children with diabetes, there are periods when blood sugar is elevated and insulin is not enough. In this regard, they have a delay in growth and development. They are prescribed somatropin preparations, which must necessarily work with in one direction. This will prevent attacks of hyperglycemia. Provided that insulin with somatropin works together, the body tolerates the action of drugs more easily.

    For the elderly, the effectiveness of somatropin has been confirmed in the treatment of diseases of the musculoskeletal system. It increases the hardness of bone tissue, its mineralization, strengthens ligaments, muscle tissue. For some, it helps in burning adipose tissue.

    Unfortunately, this type of drug is associated with an increase in blood sugar, which is unacceptable for most older people, and long-term treatment with them is excluded.

    The use of growth hormone in sports

    Since 1989, the IOC has banned this drug for use by competitive athletes. However, there is a group of "amateur" competitions in which the use and doping is not controlled - for example, some types of fights without rules, some bodybuilding competitions, powerlifting.

    The use of modern synthetic analogues of somatropin is difficult to control on doping samples, and most laboratories do not have suitable equipment.

    In bodybuilding, when people train for their own pleasure, and not for performances, these substances are used in two types of training - in the process of "drying" and in building muscle mass. In the process of drying, the intake is accompanied by a large amount of intake of thyroid hormone analogues T4. During periods of muscle building, the intake is carried out in conjunction with insulin. When burning fat, doctors recommend injecting preparations locally - in the stomach, since men have the most fat in this area.

    Pumping the relief of the body with the help of specialized substances allows you to quickly gain large muscle mass, little subcutaneous fat, however, the stomach is large. This is due to the large amount of digestible glucose when building muscle mass. However, this practice is much more effective than the use of drugs such as methyltestosterone. Methyltestosterone is able to activate the process of obesity, in which a person will have to "dry" the body.

    Female bodybuilding also did not ignore somatropin. Its analogues are used in conjunction with estrogen instead of insulin. This practice does not cause a strong increase in the abdomen. Many female bodybuilders prefer this one, because other doping drugs are associated with male hormones, cause the appearance of masculine features, masculinization.

    In most cases, it will be more effective for a bodybuilder under the age of 30 not to take somatropin. The fact is that while taking this drug, you will have to enhance its effect with the help of other hormones, the side symptoms of which (obesity) will need to be compensated for with additional efforts. The lifeline in this situation will be the use of other synthetic drugs, which also increase the endogenous production of growth hormone.