Traneksam after how many days they work. How to drink Tranexam with heavy periods? Features of the use of Tranexam

Tranexam (tranexamic acid) is a hemostatic drug. It is used to treat and prevent blood loss due to reduced blood clotting. The use of components and blood products is associated with an increased risk of developing certain complications: bacterial infection, allergies, the so-called. "Syndrome of massive transfusions". In this regard, the issue of searching for safer and more reliable blood-saving technologies is relevant. The process of hemostasis starts immediately from the moment of traumatic damage to the vessel, and ends with the formation of a hemostatic plug in the form of a platelet-fibrin network. The latter acts as a mechanical barrier to further blood loss. An imbalance in the hemostatic mechanism has two extremes as a consequence: excessive blood loss and increased thrombus formation. To date, doctors have a number of hemostatic drugs in their arsenal - direct and indirect coagulants, synthetic and animal fibrinolysis inhibitors - each of which, however, has its own limitations for use. Of particular interest in terms of hemostatic and blood-saving technology is Tranexam, a drug based on tranexamic acid. It is an antifibrinolytic that inhibits the activation of the proenzyme precursor of plasmin, plasminogen. In the medical literature, data were cited that Tranexam in its antifibrinolytic activity is two orders of magnitude superior to aminocaproic acid in vitro and an order of magnitude in vivo.

The antifibrinolytic properties of tranexamic acid were discovered in 1962 by the Japanese scientist Okamoto. Then clinical studies were carried out, which proved that pharmacotherapy with Tranexam significantly reduces the amount of blood loss and significantly reduces the need for donor blood preparations - fresh frozen plasma and erythrocyte mass. In addition, the interpretation of the coagulogram parameters confirmed a decrease in the severity of excessive fibrinolysis. Today, Tranexam is a first-line hemostatic agent with a high safety profile, effective in the treatment and prevention of massive blood loss. Reduces the volume of bleeding after surgical interventions by 30-40%. Reduces the need for blood transfusion by half. Does not increase the risk of thromboembolic complications. It has a systemic anti-inflammatory effect. It has higher efficacy and safety than aminocaproic acid preparations and aprotinin. It has half a century of application experience and a solid evidence base in various areas of medicine, including hematology, cardioanesthesiology, traumatology, obstetrics and gynecology, urology, gastroenterology, oncology, otorhinolaryngology. With massive uterine bleeding, it has proven advantages in comparison with non-steroidal anti-inflammatory drugs and etamsylate.

Pharmacology

Antifibrinolytic agent. It inhibits the action of plasmin activator and plasminogen, has a hemostatic effect in bleeding associated with an increase in fibrinolysis, as well as anti-allergic and anti-inflammatory effects by suppressing the formation of kinins and other active peptides involved in allergic and inflammatory reactions.

Release form

Tablets, coated (film) white, biconvex.

Excipients: microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, talc, calcium stearate, colloidal silicon dioxide (aerosil).

Shell composition: hypromellose, titanium dioxide, talc, polyethylene glycol 6000.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.
10 pieces. - polymer cans (1) - packs of cardboard.
20 pcs. - polymer cans (1) - packs of cardboard.
30 pcs. - polymer cans (1) - packs of cardboard.
50 pcs. - polymer cans (1) - packs of cardboard.

Dosage

Individual, depending on the clinical situation. A single dose for oral administration is 1-1.5 g, the frequency of use is 2-4 times / day, the duration of treatment is 3-15 days. A single dose for intravenous administration is 10-15 mg / kg. If it is necessary to re-use, the interval between each injection should be 6-8 hours. In case of violation of the excretory function of the kidneys, a correction of the dosing regimen is necessary: at a serum creatinine level in the blood of 120-250 μmol / l, 15 mg / kg is administered orally, intravenously - 10 mg/kg 2 times/day; at a serum creatinine level of 250-500 µmol/l - orally and intravenously in the same single dose, multiplicity - 1 time / day; with a serum creatinine level of more than 500 μmol / l - inside 7.5 mg / kg, intravenously 5 mg / kg, multiplicity - 1 time / day.

Interaction

With simultaneous use with hemostatic drugs and hemocoagulase, activation of thrombus formation is possible.

The solution should not be added to blood products and solutions containing penicillin.

Side effects

From the digestive system: loss of appetite, nausea, diarrhea, heartburn.

From the side of the central nervous system: drowsiness, impaired color vision.

Allergic reactions: incl. skin rash, itching.

Indications

Treatment and prevention of bleeding due to increased total fibrinolysis (malignant neoplasms of the pancreas, prostate; chest surgery; postpartum hemorrhage, manual removal of the placenta; leukemia; liver disease; complications of streptokinase therapy) and local fibrinolysis (uterine, nasal, gastrointestinal bleeding, hematuria, bleeding after prostatectomy, conization of the cervix due to carcinoma, tooth extraction in patients with hemorrhagic diathesis).

Hereditary angioedema, allergic diseases (eczema, allergic dermatitis, urticaria, drug and toxic rash).

Inflammatory diseases of the oral cavity (stomatitis, aphthae of the mucous membrane, pharynx (tonsillitis, pharyngitis, laryngitis).

Contraindications

Hypersensitivity to tranexamic acid.

Application features

Use during pregnancy and lactation

Adequate and strictly controlled clinical studies of the safety of the use of tranexamic acid during pregnancy have not been conducted, therefore, when prescribing, the intended benefits and potential risks of therapy should be carefully evaluated.

Application for violations of kidney function

In case of violation of the excretory function of the kidneys, a correction of the dosing regimen is necessary.

special instructions

Caution should be used in combination with heparin and anticoagulants in patients with coagulation disorders and thrombosis (cerebrovascular thrombosis, myocardial infarction, thrombophlebitis) or the threat of their development.

Before and during the treatment, it is necessary to consult an ophthalmologist (determination of visual acuity, color vision, condition of the fundus).

"Tranexam" can not only stop bleeding, but also has antitumor, anti-inflammatory, anti-allergic effects. It can be used for menopause, and during pregnancy with bleeding. It is important to know the features of taking and prescribing the medicine.

Composition and principle of action

The therapeutic effect of the drug is due to the content of tranexamic acid in the composition. The main effect of the acid is associated with the effect on the blood coagulation process.

The effect of taking

How long to take the drug traxecam, what was the effect? To maintain the liquid state of the blood and protect against the formation of clots, the body needs the sequential completion of a chain of biochemical reactions. One of the steps is the conversion of plasminogen to plasmin. Tranexamic acid inhibits this reaction by exerting an antifibrinolytic effect. As a result, the rate of formation of blood clots increases and bleeding stops.

Tranexamic acid has a systemic and local hemostatic effect. In addition, it is able to influence the formation of kinins - substances responsible for the severity of inflammation and allergies. Tranexamic acid has anti-allergic and anti-inflammatory effects. Its antitumor properties are also known, which are currently being studied.

Thus, tranexamic acid stops bleeding due to the fact that it makes the blood thicker, multiple blood clots are formed. It does not affect either the vascular wall or the platelets themselves.

When appointed

"Tranexam" is assigned with the following goals:

as a hemostatic agent- when performing any operations, as well as in case of acute bleeding in obstetric-gynecological, surgical, oncological, dental practice;
for anti-inflammatory purposes with tonsillitis, pharyngitis, laryngitis, stomatitis;
as an antiallergic drug o - with eczema, urticaria, contact dermatitis, angioedema.

Indications for the use of the drug are liver diseases, leukemia for the prevention of possible bleeding with suspected increased bleeding.

In gynecology

In 90% of cases, Tranexam is used to stop bleeding associated with increased fibrinolysis. In gynecological practice, it is used in the following conditions:

with heavy menstruation- with uterine myoma, endometriosis, hyperplasia and endometrial polyps, with dysfunctions;
after scraping - to reduce discharge after abortion, miscarriage, hysteroscopy;
with acyclic bleeding- they can appear with dysfunction, while taking oral contraceptives.

Some women are interested in whether it is possible to stop periods in this way or completely avoid them in some month. With the help of Tranexam, it is only possible to reduce the abundance and duration of bloody discharge. Reviews of practicing doctors confirm this.

During pregnancy and lactation

The drug is often used during pregnancy to stop bleeding. Its safety has not been proven in extensive studies, but long-term observation of women to whom it is prescribed according to indications proves the absence of a significant negative effect on the developing baby.

"Triniksan" is prescribed at any stage of pregnancy and after childbirth in the form of injections or tablets. It is shown in the following situations:

with the threat of miscarriage with spotting;
with retrochorial hematoma (placental abruption);
with postpartum hemorrhage;
with manual separation of the placenta.

Traneksam is also prescribed for bleeding as a result of central or marginal placenta previa. The duration of treatment should not exceed three days in women with hereditary thrombophilia, antiphospholipid syndrome, since further therapy will cause the opposite effect - termination of pregnancy.

Tranexamic acid passes into breast milk, so it is not recommended to take it during lactation. With heavy periods, which often happens when the cycle is restored after childbirth, it is better to replace Traneksam with a similar drug.

Instructions for use "Tranexam"

Tranexam is available as a solution in 1 ml ampoules containing 50 mg of tranexamic acid. At home, the drug is often used in tablets, each contains 250 mg. How to drink "Tranexam" with heavy periods and use it in case of other bleeding can be seen in the table.

Table - the use of "Tranexam"

Tranexamic acid after metabolic transformations is excreted by the kidneys. Therefore, in case of violation of their work, the doses must be adjusted taking into account creatinine clearance and other important analyzes that reflect the state of the organ.

Who should not use

The use of Transekam tablets, and even more so intravenous injections, should be prescribed by a doctor. The drug has contraindications and side effects. You should not use the medicine for:

recorded allergic reactions to it;
acute thrombosis;
high risk of thrombosis (thrombophlebitis, heart attack);
violation of color vision;
kidney failure.

Against the background of taking Tranexam, the following adverse reactions are possible:

dyspepsia - nausea, vomiting, heartburn, loss of appetite;
disruption of the CNS- dizziness, weakness, drowsiness;
cardiovascular disorders- thrombosis, thromboembolism, pressure reduction;
allergic manifestations- urticaria, itching, Quincke's edema, anaphylactic shock.

If you have complaints while taking the medication, you should immediately seek medical help. There are no data on drug overdose.

Other Features

If it is prescribed to drink "Transikam" to stop menstruation or another type of bleeding, this should not be combined with taking other hemostatic agents. Such combinations can lead to activation of thrombus formation and serious complications. Also, you should not combine "Tranexam" with the following drugs:

blood components;
penicillins;
tetracyclines;
"Dipyridamole";
"diazepam";
hypertensive agents.

Analogues

Complete analogues of the drug are the following drugs:

"Trenax";
"Tugina".

The following drugs act on different mechanisms than Tranexam, but also give a hemostatic effect:

"Etamzilat";
"Ascorutin".

Tranexam is one of the most effective hemostatic drugs. Helps literally five minutes after intravenous administration. This action is especially important during surgical interventions. Reviews of "Tranexam" for uterine bleeding also prove its high efficiency and safety, subject to the rules of admission and doctor's recommendations.

Reviews: "Powerful thing"

Tranexam is a powerful thing. I was prescribed, but I did not drink it for long, 2-3 days. I think you will also take it for a short time, as soon as it stops bleeding, it will be canceled. I understand that it is unpleasant to swallow pills with handfuls, but there is nowhere to go. And he does not harm the lyalka. Recover!

Forget-me-not, https://deti.mail.ru/id1004369158/

I have a placenta previa, this Monday also began a small discharge. I came to the hospital in an ambulance, they looked there and allowed me to go home, but they prescribed complete rest and tranexam for 5 days, 4 tablets a day, to drink. The discharge disappeared in the evening after taking the drug, now I feel good. Health to you!

Natalia, https://deti.mail.ru/id1013684767/

Hello! I’m 15 years old, I had very heavy periods, it was pouring like a bucket, I went to the gynecologist, she prescribed tranex, she said if she doesn’t stop pouring, then I have to go to the hospital, my periods have passed, but after that I have not had periods for 2 months .

Liana, https://www.baby.ru/u/usr1777667/

Tranixam drank 2. Tablet 3 times a day for 3 days helped, so it rained for 20 days (for foolishness, to get rid of painful periods, I experimented with duphaston, the result of menstruation without stopping)

Polkinamamka, https://www.baby.ru/u/soleveig/

After the birth, bleeding began, which could not be stopped. The hospital prescribed a dropper (Tranexam). They did a few drops and everything stopped. Thanks, it helped!

Marina, https://www.rlsnet.ru/comment/traneksam

"Tranexam" during pregnancy is used most often. Because the drug is aimed at eliminating the risk of miscarriage. Available in 2 forms - tablets and solution for drip or jet injection. During pregnancy, a tablet preparation is most often prescribed, but another option is also possible.

Composition and properties

"Tranexam" refers to a fibrinolysin inhibitor, due to which bleeding is prevented and stopped. Thanks to tranexamic acid, silicon dioxide, microcrystalline cellulose and sodium glycolate, which is part of the drug, the following action is carried out:

The drug contributes to the suppression of kinins and some peptides, due to which the allergic reaction and inflammatory processes are eliminated. Therefore, "Tranexam" has anti-inflammatory, antiallergic, antitumor properties.
The blood thickens and the process of incoagulability accelerates, which is especially important for bleeding.
The uterine tone decreases, due to which there is a risk of miscarriage.
If the drug is taken for a long time, then it has an analgesic effect, that is, an anesthetic.

"Tranexam" is prescribed for pregnant women in such cases:

bloody issues:
pulling pain in the lower abdomen;
premature aging of the placenta;
exfoliation of the fetal egg;
propensity to allergies;
inflammatory processes;
if you have had miscarriages before;
miscarriage is suspected.

The drug is prescribed in order to prevent heavy bleeding after childbirth. And also with heavy or painful menstruation.

The effect of tranexamic acid on the body of a pregnant woman

The main active ingredient of Tranexam is tranexamic acid. It is obtained from the amino acids lysine in a synthetic way.

The peculiarity of the substance is that there is no metabolism, due to which the acid is fully excreted from the body through the kidneys through the urine. It does not penetrate the placenta of the fetus, therefore it is a completely safe remedy.

"Tranexam" is used in medicine not only during pregnancy, but also in other cases. For example, with any bleeding, heavy menstruation.

Quite often, with minor hemorrhages, a hematoma of the uterus is formed. That is, in a certain area of \u200b\u200bthis organ, a certain amount of blood accumulates, which is subsequently converted into a neoplasm. And this leads to serious consequences. Hematomas are formed in cases where a woman has a violation of blood clotting. "Tranexam" promotes the resorption of these hematomas, as the blood structure is restored.

Possible contraindications and side effects

In some cases, there are adverse reactions:

nausea and vomiting;
heartburn and weakness;
temporary deterioration in visual acuity;
dizziness and rapid heartbeat;
pain in the sternum;
thrombosis;
allergies - skin rashes, accompanied by itching and burning.

Contraindications:

It is strictly forbidden to use the drug for varicose veins, thrombophlebitis and thrombosis.
Intolerance to one of the components of Tranexam.
Bleeding of a subarachnoid nature.
Pathological disorders of the functionality of the renal system.
Circulatory disorders in the brain.
Breastfeeding, as the active substances easily pass into milk.
An increased number of red blood cells in the urine, that is, hematuria.
Intravenously, the drug is not prescribed in the case when a blood transfusion was performed.
It is forbidden to use "Traneksam" together with preparations containing penicillin and tetracycline.
Tranexamic acid is incompatible with other hemostatic agents and drugs intended to lower blood pressure.

How and how much you can drink "Tranexam" during pregnancy - dosage

Each human body has individual characteristics. So pregnancy is different. But the risk of miscarriage in the first trimester exists in almost every woman. There are many reasons for this. However, the drug "Tranexam" is considered universal, as it is used in all cases.

The most commonly prescribed tablet form. In this case, the tablets are used three times or four times a day, 1 or 2 units, depending on the purpose. You need to drink tablets immediately after eating. The duration of the course of treatment varies from indications. So, a woman can use the drug for 1 week or several. There are no restrictions in the course of admission, since Traneksam is not addictive.

If the doctor prescribes an injection solution, then its dosage depends on the purpose of therapy:

In case of bleeding from the uterus and hematoma, the drug is administered drip by dropper 2-3 times a day, 1,000-1,500 mg each.
If bleeding is detected in the first months of pregnancy, then the dosage is from 250 to 500 mg. The drug is administered four times a day.
If an allergic reaction or inflammatory processes is noted, then Traneksam is prescribed twice a day for 1,000-1,500 mg. It is enough to drop 2 times.
With generalized fibrinolysis, a dropper is initially placed, and then a tablet form of the drug is prescribed.

The decision to prescribe the dosage of Tranexam is made at the individual level. It depends on the course of the disease and pregnancy, the characteristics of the body, the level of blood loss, etc.

Application at various times

On the first trimester tranexamic acid is prescribed in such cases:

inflammatory processes;
tumor neoplasms;
spotting and bleeding;
risk of miscarriage;
allergic to any allergen;
pharyngitis;
tonsillitis;
hemophilia;
leukemia;
pathology of the liver;
angioedema;
intoxication.

Second trimester:

pain syndrome in the lower abdomen of a pulling and aching character;
spotting, blood loss;
the risk of losing a child.

Third trimester:

stomach ache;
the threat of premature birth;
bleeding and spotting.

What is better to take: "Dicinon" or "Tranexam" during pregnancy?

The drug "Dicinon" refers to the analogue of the drug "Tranexam". However, they have a slight difference. First, it's cost. For example, "Tranexam" (10 tablets) has a price of 230-260 rubles, and "Dicinon" for the same amount - 40-50.

Secondly, the effectiveness of the second is largely different from tranexamic acid, because Tranexam is such a strong drug that it is often used as a first aid agent. That is, it can stop the bleeding instantly.

Thirdly, the side reactions of Dicinon are less pronounced. But both types of drugs are produced in both tablet and injectable form. And what to choose specifically for you, the doctor should decide.

Pros and cons of taking

Benefits and taking the drug "Tranexam":

instant therapeutic effect;
safety for mother and unborn child;
relatively low cost of the drug;
the ability to use for a long time - no addiction;
in some cases, the duration of the course is only a few days;
comprehensive effect on the body;
can be bought at any pharmacy.

Disadvantages:

it is necessary to strictly adhere to dosages;
there are a number of contraindications;
sometimes there are adverse reactions.

Summing up, it should be noted that Traneksam is a fairly effective and safe remedy that will help not only stop bleeding, but also get rid of many other problems. He has many analogues, but only a doctor should be involved in the selection.

The use of tranexam in uterine bleeding

Uterine bleeding can be a life-threatening condition, lead to iron deficiency, and, accordingly, a significant decrease in the quality of life. There are many drugs that are used to reduce blood loss. But choosing your own hemostatic drugs for uterine bleeding is not worth it. After all, the causes of pathology can be very serious, up to oncology. Self-medication will not lead to good.

If the doctor examined you and gave recommendations on how to stop uterine bleeding, some options are possible. For example, if you have been prescribed a decoction of nettle or some other folk remedy, then you may well replace it with a medication if the instructions for it do not reveal any contraindications for you.

If the issue of tranexam or dicynone for uterine bleeding is better to use, then the first drug, since it acts much faster and more efficiently. But keep in mind that both drugs have side effects. So, tranexam tablets with bleeding from the uterus can provoke heartburn, nausea, and drowsiness. Less often thrombosis and thromboembolism, tachycardia. There may be allergic reactions. When prescribing large dosages, the doctor usually advises the patient to undergo an examination by an ophthalmologist, he must check visual acuity and the condition of the fundus.

How to take tranexam with uterine bleeding, how many times a day and how many tablets? No one can answer this question for you. For example, the dosage for heavy menstruation is 1 tablet 3 times a day. And with profuse uterine bleeding many times more - take 4-6 tablets of 250 mg 2-3 times a day until the bleeding ends. But, of course, such a large dosage should be taken under close medical supervision, since in this case the risk of side effects increases dramatically.

How to drink tranexam with uterine bleeding that occurred after menopause is generally not a question for independent decisions. If in young women extramestrual discharge is most often caused by benign processes in the endometrium and hormonal pathologies, then in older women there is a high probability of oncology. And a woman should not look for reviews about tranexam with uterine bleeding, but go to a doctor who, most likely, will refer her for diagnostic cleaning (she will stop the blood) or take an aspirate from the uterus (histological analysis) followed by the appointment of antibacterial and hemostatic tablets.

Content

With excessive formation of blood in the uterus, doctors prescribe Tranexam to patients - instructions for the use of the drug also include indications for the use of other bleeding. The drug stops the process of excessive blood production, helps to cope with hematopoietic diseases. Read the instructions for use.

Tranexam drug

According to the clinical and pharmacological classification, Tranexam refers to drugs with hemostatic and antitumor effects. It is an inhibitor of fibrinolysis - the process of transition of plasminogen substance to plasmin, which are involved in hematopoiesis. The active substance of the drug is tranexamic acid. It helps stop blood production and prevent uterine bleeding. According to indications, doctors prescribe Tranexam - this is stated in the instructions for the use of the drug.

Composition and form of release

There are two forms of Tranexam release - oral tablets and solution for parenteral administration. Detailed composition of each type:

	Tablets	Solution for intravenous injection
Tranexamic acid concentration, mg	250 or 500 for 1 pc.	50 per 1 ml, 250 per 1 ampoule
Additional components	Hyprolose, macrogol, calcium stearate, talc, carboxymethyl starch, titanium dioxide, microcrystalline cellulose, colloidal silicon dioxide
Description	Film-coated, white, biconvex, on a cream or gray medium	Clear, colorless solution with a light brown tint
Package	10 or 30 pcs.	5 ml per ampoule, 5 or 10 ampoules with instructions for use

Pharmacodynamics and pharmacokinetics

The mechanism of action of the active substance of Tranexam is that the acid specifically affects the activation of plasminogen, inactivates it, preventing it from turning into plasmin. Locally systemically hemostatically acts on bleeding associated with an increase in the concentration of fibrinolysis (platelet pathology, menorrhagia). By suppressing the production of kinins and active proteins involved in allergic reactions, it has an anti-allergic and anti-inflammatory effect.

When taken orally, up to 50% of the drug is absorbed, the maximum concentration is reached after three hours. It binds to plasma proteins, crosses the placental barriers, is excreted in breast milk at a concentration of 1%. Acts for 17 hours in tissues, 7-8 hours in plasma. In case of impaired renal function, there is a risk of accumulation of the active substance. When administered intravenously, the analgesic activity of the drug was confirmed.

Indications for use

According to the instructions for use, indications for use differ depending on the form of release. Under medical supervision, the drug is used for the following factors:

thrombosis of cerebral vessels;
thrombophlebitis of deep veins;
thromboembolic syndrome;
myocardial infarction;
the threat of thrombosis;
thrombohemorrhagic complications;
violation of color vision;
hematuria of the urinary tract;
kidney failure.

Tranexam tablets

According to the instructions for use, Tranexam hemostatic tablets have the following indications for use:

uterine, postpartum, nasal, gastric bleeding, after removal of the prostate, extraction of the tooth with hemorrhagic diathesis;
the risk of bleeding against the background of enhanced local fibrinolysis, against the background of von Willebrand disease or other coagulopathy;
hematuria;
malignant tumors;
angioedema of a hereditary type;
allergic reactions (eczema, urticaria, drug rash, dermatitis);
tonsillitis, pharyngitis, stomatitis, laryngitis.

Tranexam in ampoules

According to the instructions for use, Tranexam solution can be used for the following indications:

bleeding during or after surgery;
bleeding during pregnancy;
pancreatic or prostate cancer;
hemophilia;
hemorrhagic complication;
leukemia;
streptokinase therapy;
bladder surgery;
surgical intervention for sepsis, peritonitis, preeclampsia, shock, pancreatic necrosis.

Method of application and dosage

According to the instructions for use, the Tranexam solution is administered intravenously, drip, with a string. The dosage and rate of administration of the hemostatic drug depends on the disease:

	Dose, mc/kg	Mode, every X hours	Note
Generalized fibrinolysis	Single 15		Rate 1 ml/min
local fibrinolysis		2-3 times / day
Prostatectomy or bladder surgery	1 g during operation, 1 g		Duration three days, transfer to tablets
High risk of bleeding, systemic inflammatory disease			Half an hour before surgery
Coagulopathy before tooth extraction
In case of violation of the excretory function of the kidneys, the dose is adjusted and is 5-10 mg / kg 1-2 times / day

Tranexam oral tablets are administered orally. Dosage, course and regimen depend on the type of disease:

Disease	Dosage, g	Once/day	Course, days
Profuse uterine bleeding
Bleeding with coagulopathy
After tooth extraction in patients with coagulopathy
hereditary angioedema
Allergy and inflammation
Generalized fibrinolysis
local fibrinolysis
After conization of the cervix
Nose bleed
Bleeding during pregnancy
In case of impaired renal function, the dose is adjusted and ranges from 500 mg to 1 g 1-2 times / day

Tranexam for uterine bleeding

In gynecological practice, Tranexam is used to stop bleeding from the uterus. Indications for prescribing the drug are blood discharge in pregnant women, the threat of miscarriage, the duration of bleeding for more than a week, large clots were found in the blood. The dosage is 1-1.5 g tablets 2-4 times / day for a maximum of 14 days. The therapy is repeated for no more than three menstrual cycles. The duration of treatment with the solution is a maximum of three days.

With menstruation

Violation of the flow of menstruation requires a reason to see a doctor. Tranexam during menstruation can be used if too heavy bleeding is observed. The standard method of administration is 3-4 tablets / day from the first day of the cycle. Sometimes doctors prescribe a different scheme - on the first day 4 tablets, on the remaining one at a time. The dosage depends on the individual characteristics of the patient.

If you want to delay the arrival of menstruation, you can use this medication. This is rarely allowed, otherwise the hormonal background may go astray, the composition of the blood will change in a negative direction. If you drink one tablet every 8 hours 1-2 before the onset of menstruation, it will be delayed by 3-4 days. To stop long periods (over a week), the medication is taken 1 tablet every 6-8 hours for a maximum of 8 days. Normally running menstruation does not need to be stopped, this will lead to inflammatory processes in the uterus.

Instructions for use during pregnancy

If there are indications (threat of miscarriage, bleeding) during pregnancy, gynecologists prescribe Tranexam according to the instructions. Contraindications must be taken into account, because tranexamic acid crosses the placental barrier and may affect the development of the fetus. During breastfeeding, the active substance passes into breast milk.

special instructions

Before starting therapy with Tranexam, the patient should be examined by an oculist to assess visual acuity, color perception, and the condition of the fundus. This is necessary because the drug affects these indicators. Animal studies have not revealed teratogenic and embryotoxic effects on fetal development. Do not exceed the dosage indicated in the instructions.

drug interaction

According to the instructions, the use of Tranexam may affect other drugs:

incompatible with blood products, solutions of penicillin, urokinase, hypertensive agents, tetracyclines, dipyrdamole, norepinephrine, diazepam;
hemostatic agents and hemocoagulase activate the process of thrombus formation.

Side effects

The instructions for use say about the side effects that may occur when taking the medication:

loss of appetite, heartburn, vomiting, diarrhea, nausea;
dizziness, drowsiness, blurred vision and color perception;
thrombosis, thromboembolism;
skin rash, urticaria, itching, allergic reactions;
anorexia, weakness, tachycardia;
pain in the region of the heart;
hypotension.

Contraindications

For the use of the drug, there are certain contraindications, in which its use is strictly prohibited:

subarachnoid hemorrhage (between the meninges, occur spontaneously);
hypersensitivity to drugs;
thrombosis;
kidney failure;
hematuria of the urinary system;
problems with color perception.

Terms of sale and storage

By prescription from pharmacies, 250 mg tablets and a solution are dispensed, 500 mg tablets can be bought without it. The drug is stored at a temperature not exceeding 30 degrees for tablets and 25 for a solution. The shelf life is three years.

Tranexam analogue

Structural analogues of Tranexam and similar in pharmacological action are the following preparations in the form of tablets and solution, produced in Russia and other countries:

Stagemin;
Traxara;
Troxaminate;
Transamcha;
Ingitril;
Exacil;
Amben;
Vikasol;
Aprotex;
Polycapran;
Aprotinin;
Gumbix;
Contrykal;
Dicynon;
Traskolan.

Tranexam price

You can buy the drug through the Internet or the usual pharmacy departments. The cost will depend on the chosen format of the medicine and the number of tablets in the package. Approximate prices are listed below.